12/11/2008

Review Links Dioxin to Increased Heart-related Mortality Rate

Dioxins, environmental pollutants resulting from the production and combustion
of chlorinated compounds, have been linked to an increase in ischemic heart
disease (IHD) and cardiovascular disease (CVD) mortality rates, as reported in
a review article in the November 2008 issue of the peer-reviewed journal
Environmental Health Perspectives (EHP).

A December 2007 PubMed search of English-language epidemiologic studies and
their citations regarding dioxin exposure and CVD mortality provided the basis
for the systemic review. The authors, researchers at the Harvard School of
Public Health and the U.S. Environmental Protection Agency, selected studies on
original mortality data from all cases of CVD or IHD. They excluded studies of
leather, flavor, and fragrance workers, whose occupational exposures typically
include not only dioxin but also cardiotoxic methylmercury, arsenic, and
xylene. Finally, they grouped the studies by their quality, according to two
well-recognized criteria. The studies considered to be of the highest quality
found consistent and significant dose-related associations with IHD mortality
and more modest associations with all-CVD mortality.

Although a number of epidemiologic studies have examined the association of
dioxin exposure with CVD morbidity or mortality, the authors found no published
systematic reviews on this topic. This is possibly because dioxin epidemiology
research has focused primarily on the association with various cancers.

The authors wrote that future studies in both animals and humans should assess
whether cardiovascular effects are present at environmentally relevant doses of
dioxin.


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AplusA-online.de - Source: Environmental Protection