14.02.2018

State-of-the-art report on reproductive toxicants

Exposure to chemical substances can cause adverse effects on the
male and female reproductive systems. Reproductive toxicity may be expressed as
alterations in sexual behavior, decreases in fertility, or loss of the fetus
during pregnancy. A reproductive toxicant may interfere with the sexual
functioning or reproductive ability of exposed individuals from puberty
throughout adulthood. Toxicants that target the female reproductive system can
cause a wide variety of adverse effects. Changes in sexual behavior, onset of
puberty, cyclicity, fertility, gestation time, pregnancy outcome, and lactation
as well as premature menopause are among the potential manifestations of female
reproductive toxicity: all can disrupt a woman's ability to successfully
reproduce. Exposure to lead, for example, can result in menstrual disorders and
infertility. The toxicants carbon disulfide, mercury, and polychlorinated
biphenyls (PBCs) have been shown to cause irregularities in the menstrual
cycle. Toxicants that target the male reproductive system can affect sperm count
or shape, alter sexual behavior, and/or increase infertility. Carbon disulfide and the
pesticides chlordecone(kepone), ethylene dibromide (EDB), and dibromochloropropane (DBCP)
are examples of chemicals known to disrupt male reproductive health.

A summary, published by the European Agency for Safety and Health at Work,
presents in short the results of a report that examines the current knowledge
on workplace risks to reproduction.

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AplusA-online.de - Source: European Agency for Safety and Health at Work